Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK)

Bioorganic & Medicinal Chemistry, pp. 800-814, 2007.

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Abstract:

Molecular modeling studies led to the identification of LFM-A13 (α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide) as a potent inhibitor of Polo-like kinase (Plk). LFM-A13 inhibited recombinant purified Plx1, the Xenopus homolog of Plk, in a concentration-dependent fashion, as measured by autophosphorylation and phosphorylation...More

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