Robust Hepatitis C Genotype 3a Cell Culture Releasing Adapted Intergenotypic 3a/2a (S52/JFH1) Viruses

    Gastroenterology, pp. 1614-1626, 2007.

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    50% tissue culture infectious doseffuaa(s)nucleotide(s)urokinase plasminogen activator-severe combined immunodeficiencyMore(14+)

    Abstract:

    Background & Aims: Recently, full viral life cycle hepatitis C virus (HCV) cell culture systems were developed for strain JFH1 (genotype 2a) and an intragenotypic 2a/2a genome (J6/JFH). We aimed at exploiting the unique JFH1 replication characteristics to develop culture systems for genotype 3a, which has a high prevalence worldwide. Meth...More

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