Potent antibacterial lysine–peptoid hybrids identified from a positional scanning combinatorial library

We describe the synthesis and screening of a positional scanning library made up of N-alkylglycines and lysines. Compounds with potent antibacterial activity and low hemolytic activity were identified including [N-(cyclohexylmethyl)glycyl]-[N-(1-methylhexyl)glycyl]-[N-(4-methylbenzyl)glycyl]-[N-(2-(3-chlorophenyl)ethyl)glycyl]-lysyl-lysyl-lysine amide.