Investigation of glycine α-ketoamide HCV NS3 protease inhibitors: Effect of carboxylic acid isosteres

Wei Han,Xiangjun Jiang,Zilun Hu,Zelda R. Wasserman,Carl P. Decicco

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

A series of tetrapeptide-based α-ketoamides with acid isosteres, such as tetrazole, sulfonic acid, and N-sulfonylcarboxamids, as prime groups were designed, synthesized, and evaluated as HCV NS3 protease inhibitors. Potent inhibitors with IC50 of 0.02–0.060μM were identified.

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HCV protease inhibitors

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