A High-Fat Meal In Hypertensive Patients Postprandial Hypertriglyceridemia Associated With Inflammatory Response And Procoagulant State After

Objective To investigate the changes of inflammatory factors and hemostatic variable in plasma after a high-fat meal in normocholesterolemic patients with essential hypertension.Methods A total of 60 hypertensive patients were randomly assigned to accept a single high-fat meal (group 1, n=40) or not (group 2, n=20) in the morning after an overnight fast, and 20 healthy participants (group 3) consumed a single high-fat meal on the same day. Plasma lipid profiles, high-sensitivity C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF alpha), soluble P-selectin and plasminogen activator inhibitor type 1 (PAI-1) antigen levels were measured at fasting and 4 h after meal ingestion.Results Postprandial triglyceride levels increased significantly in groups 1 and 3 (P < 0.01), whereas levels were higher in group 1 (P < 0.001). Postprandial plasma TNFa hsCRP, soluble P-selectin and PAI-1 antigen levels increased in group 1 (P < 0.001) but not in group 3. Postprandial plasma triglyceride level was correlated with log(hsCRP) (P < 0.001),TNF alpha (P < 0.001), soluble P-selectin (P < 0.01) and PAI-1 antigen (P < 0.05) levels, respectively. Both postprandial plasma level of soluble P-selectin and that of PAI-1 antigen were positively and significantly correlated with those of log(hsCRP) (P < 0.01) and TNF alpha (P < 0.001), respectively.Conclusion Postprandial hypertriglyceridemia in hypertensive patients is associated with inflammatory response and procoagulant state.