Oxytocin deficiency impairs maternal skeletal remodeling.
Biochemical and Biophysical Research Communications(2009)
摘要
We have reported that the posterior pituitary hormone, oxytocin (OT), known for its effects in inducing parturition, lactation and social bonding, is also a skeletal hormone. Here, we demonstrate that OT plays a key role in enabling maternal skeletal mobilization during pregnancy by enhancing the formation of bone resorbing osteoclasts. Osteoclast formation ex vivo is thus diminished in pregnant mothers with genetic OT-deficiency. OT−/− pups at day E20 also show a defect in trabecular bone. μCT measurements reveal normal bone volume, but increased trabecular numbers, suggesting that trabeculae in OT−/− pups are hypomineralized. We suggest that OT facilitates intergenerational transfer of calcium ions from a pregnant mother to the pups.
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关键词
Pituitary hormones,Osteoclast,Osteoblast,Bone density
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