Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2
Bioorganic & Medicinal Chemistry Letters（2010）
摘要
The discovery and SAR of the isozyme non-selective acetyl-CoA carboxylase 1 and 2 inhibitor 59 is described.
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关键词
Acetyl-CoA carboxylase,ACC,Enzyme inhibitor,Spirochromanone,ACC1,ACC2,Structure based drug discovery,Diabetes,Metabolic syndrome
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