Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors
Bioorganic & Medicinal Chemistry Letters（2009）
摘要
A series of benzothiazole derivatives is shown to be potent MTP inhibitors, with some showing oral activity in a mice diet-induced obesity model.
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关键词
derivatives,body weight,microsomal triglyceride transfer protein,pharmacodynamics,obesity
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