Immuno-gene Therapy for Metastatic Prostate Cancer
msra(2008)
摘要
It has long been appreciated that a significant number of prostate cancers will not progress to clinical significance, yet
some prostate cancers disseminate rapidly leading to lethal metastatic disease. Therefore, a reasonable goal of prostate cancer
research is to develop novel alternative interventions and adjuvant therapeutic approaches that would suppress local tumor
growth and/or impact pre-existing metastatic disease. This chapter will describe the potential for gene therapy to achieve
this goal. We will review both pre-clinical and clinical studies using in situ gene therapy to generate a systemic immune response. These therapeutic strategies include a cytotoxic approach using the
HSV-tk gene combined with the prodrug ganciclovir, the immune modulator gene for interleukin-12, and a novel gene that is both cytotoxic
and immunomodulatory, Related to Testes-specific, Vespid and Pathogenesis proteins-1 (RTVP-1).
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关键词
gene therapy,metastasis,immune therapy,prostate cancer
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