Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation
Bioorganic & Medicinal Chemistry Letters(2009)
摘要
A reported IKKβ inhibitor to inhibit NF-κB transcriptional activities in Jurkat T cells was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling independent to IKKβ in HUVEC cells.
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关键词
NF-κB,Activator,Quinazoline,HUVEC cells
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