Glucose turnover in adult non-growing tumour-bearing mice.

1.1. [6-3H]glucose was used for measurements of plasma glucose turnover in adult non-growing mice with sarcoma-induced malnutrition.2.2. Plasma glucose turnover was increased in freely-fed tumour-bearing mice but not in starved tumour-bearing mice.3.3. Elevated glucose turnover in freely-eating sarcoma-bearing mice was associated with an increased glucose pool, the latter not only being due to an expanded distribution volume of glucose.4.4. Plasma lactate was elevated in sarcoma-bearing mice independently of their food intake.5.5. The results show that elevated plasma glucose turnover in an anorectic tumour-bearing host is not due to insufficient adaptation to food depression.6.6. Increased glucose turnover in tumour-bearing mice was associated with an altered intermediary whole body metabolism of glucose which is not entirely accounted for by the state of malnutrition of the host.