SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer.
Philip Wickens,Harold Kluender,Julie Dixon,Catherine Brennan,Furahi Achebe,Antonella Bacchiocchi,Don Bankston,Donald Bierer,Michael Brands,Debbie Braun,Melissa S Brown,Chih-Yuan Chuang,Jacques Dumas,Istvan Enyedy,Gloria Hofilena,Zhenqiu Hong,Tim Housley,Benjamin Jones,Uday Khire,Charles Kreiman,Ellalahewage Kumarasinghe,Timothy Lowinger,Ronda Ott-Morgan,Louise Perkins,Barton Phillips,Robert Schoenleber,William J Scott,Ryan Sheeler,Anikó Redman,Xiuying Sun,Ian Taylor,Lei Wang,Scott Wilhelm,Xiaomei Zhang,Mingbao Zhang,Elizabeth Sullivan,Christopher Carter,Mark Miglarese,Joan Levy Bioorganic & Medicinal Chemistry Letters（2007）
摘要
Novel series of anthranilamide type molecules that are active as inhibitors of B-RAF, c-KIT, and VEGFR-2 were identified.
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关键词
Kinase,Cancer,Anthranilamide
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