Thiazolo[4,5-D]Pyrimidine Thiones And -Ones As Corticotropin-Releasing Hormone (Crh-R1) Receptor Antagonists

A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants. (C) 1999 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.