Selective inhibition of low affinity IgE receptor (CD23) processing: P1' bicyclomethyl substituents.

Using a variety of alpha-hydroxy hydroxamic acid derivatives, the size and shape of the S-1' pocket for the CD23 processing metalloprotease has been explored. It has been demonstrated that a P-1' 2-naphthylmethyl group occupies most of the available space and gives excellent selectivity against fibroblast collagenase (matrix metalloproteinase-1, MMP-1) and other MMPs. (C) 1999 Elsevier Science Ltd. All rights reserved.