The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

Novel benzazepine sulfonamides and sulfones are potent, selective motilin receptor agonists. Hit identification and lead optimisation of this new peptide GPCR ligand series is described.

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关键词

Motilin,7TM,Benzazepine,Agonist

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