Long pentraxin PTX3 deficiency worsens LPS-induced acute lung injury

Intensive care medicine, Volume 37, Issue 2, 2011, Pages 334-342.

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Keywords:
acute respiratory distress syndromeneutrophil infiltrationcell deathtissue factortransgenic micetissue factortumor necrosis factor alphainnate immunitywild typeMore(1+)

Abstract:

Long pentraxin PTX3 is an inflammatory mediator and a component of the humoral arm of innate immunity. PTX3 expression is increased in animals with acute lung injury (ALI) and in patients with sepsis or acute respiratory distress syndrome and is considered to be a potential biomarker for these diseases. However, the role of PTX3 in the pa...More

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