Ketamine Inhibits C-Jun Protein Expression In Mouse Hippocampus Following Cerebral Ischemia/Reperfusion Injury
NEURAL REGENERATION RESEARCH(2012)
摘要
A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediately following ischemia/reperfusion significantly decreased infarct volume. Ketamine injection immediately after ischemia or ischemia/reperfusion inhibited c-Jun protein expression in mouse hippocampus, but nuclear factor kappa B expression was unaltered. In addition, the Longa scale score for neural impairment was not reduced in mice following cerebral ischemia/reperfusion. These results indicate that ketamine can protect mice against cerebral ischemia and reperfusion injury by modulating c-Jun protein expression in mouse hippocampus.
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关键词
ketamine, ischemia/reperfusion, c-Jun, nuclear factor kappa B, infarct volume
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