Peptide bond formation destabilizes Shine–Dalgarno interaction on the ribosome
NATURE（2007）
摘要
How the Shine–Dalgarno (SD) sequence affects binding of the ribosome to mRNA is examined by measuring the force required to tear the ribosome from an mRNA with or without the SD sequence. This finds that the SD sequence stabilizes the ribosome–mRNA interaction before the first peptide bond is formed, but that once this occurs, the SD sequence can no longer stabilize it.
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Nature, science, science news, biology, physics, genetics, astronomy, astrophysics, quantum physics, evolution, evolutionary biology, geophysics, climate change, earth science, materials science, interdisciplinary science, science policy, medicine, systems biology, genomics, transcriptomics, palaeobiology, ecology, molecular biology, cancer, immunology, pharmacology, development, developmental biology, structural biology, biochemistry, bioinformatics, computational biology, nanotechnology, proteomics, metabolomics, biotechnology, drug discovery, environmental science, life, marine biology, medical research, neuroscience, neurobiology, functional genomics, molecular interactions, RNA, DNA, cell cycle, signal transduction, cell signalling
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