Function of indoleamine 2, 3-dioxygenase in viral infection

The enzyme indoleamine 2,3-dioxygenase(IDO), which catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan degrada- tion,plays a key role in the antiviral immune. IDO mediates IFN-γantivirus and serves immu- noregulatory and tolerogenic functions.In this review,we introduce the studies on the antiviral immune of IDO in viral infection.