Structure Determination of Macromolecular Complexes by Experiment and Computation
msra(2008)
摘要
The function of a protein is defined by its interactions with other molecules in its environment. The interactions can be
either transient, such as protein–protein interactions involved in intracellular signaling, or relatively stable, such as
the protein-protein and protein–RNA interactions in ribosomes. A structural description of these interactions is an important
step toward understanding the mechanisms of biochemical, cellular, and higher order biological processes. There is a need
to integrate structural information gathered at multiple levels of the biological hierarchy–from atoms to cells–into a common
framework. Recent developments in several experimental and computational techniques allow structural biology to shift its
focus from the structures of the individual proteins to larger assemblies (Sali et al. 2003; Baumeister 2002).
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络