Tyrenes: synthesis of new antiproliferative compounds with an extended conjugation.

Peter Demin,Olga Rounova,Thomas Grunberger,Lorand Cimpean,Nigel Sharfe,Chaim M Roifman

Bioorganic & Medicinal Chemistry（2004）

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摘要

A series of substituted styryl-acrylonitriles was synthesized and tested for the ability to inhibit acute lymphocytic leukemia cancer cell growth. The compounds revealed great potency as antitumor agents.

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关键词

Tyrene,Antiproliferative activity,Michael acceptor

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