Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase

William J. Pitts,Junqing Guo,T.G.Murali Dhar,Zhongqi Shen,Henry H. Gu,Scott H. Watterson,Mark S. Bednarz,Bang-Chi Chen,Joel C. Barrish,Donna Bassolino,Daniel Cheney,Catherine A. Fleener,Katherine A. Rouleau,Diane L. Hollenbaugh,Edwin J. Iwanowicz

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

A series of novel triazine-based small molecule inhibitors (IV) of inosine monophosphate dehydrogenase was prepared. The synthesis and the structure–activity relationships (SAR) derived from in vitro studies are described.

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structure activity relationship

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