Biocompatibility and in vitro antineoplastic drug-loaded trial of titania nanotubes prepared by anodic oxidation of a pure titanium

TiO 2 nanotube (NT) arrays have been prepared by anodic oxidation of a Ti sheet, and carbon-deposited TiO 2 NT arrays have been prepared by annealing TiO 2 NT arrays in carbon atmosphere. The biocompatibility of the as-prepared NT arrays was investigated by observing the growth of osteosarcoma (MG-63) cells on the NT arrays. The application of the TiO 2 NT arrays as a drug delivery vehicle was investigated. Both the TiO 2 NTs and the carbon-modified TiO 2 NTs have good biocompatibility supporting the normal growth and adhesion of MG-63 cells with no need of extracellular matrix protein coating. The one end-opened TiO 2 NTs can be easily filled with drugs, working as an efficient drug delivery vehicle.