Reactions of aminoguanidine and guanidine with 3- and 5-formyl-4-arylaminopyridones

M. I. Medvedeva, N. Z. Tugusheva,L. M. Alekseeva, M. A. Kalinkina, V. A. Parshin,V. V. Chernyshev,V. I. Levina, N. B. Grigor’ev,A. S. Shashkov,V. G. Granik

Russian Chemical Bulletin（2011）

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摘要

Amidinohydrazones were prepared by the condensation of 4-arylamino-2-oxo-5-formyl-1,2-dihydropyridine-3-carbonitriles and 4-arylamino-2-oxo-1,2-dihydropyridine-3-carbaldehydes with aminoguanidinium carbonate with the purpose to investigate their biological activity as putative NO donors. The reaction of 5- и 3-formylpyridones with diguanidinium carbonate was studied. The formation of stable complexes of 4-arylamino-5-formyl-2-oxo-1,2-dihydropyridine-3-carbonitriles with aminoguanidine and guanidine was discovered. Amidinohydrazones obtained possess antiinflammatory, antidiabetic, and antihypertensive activities.

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关键词

4-arylamino-5-formyl-2-oxo-1,2-dihydropyridine-3-carbonitriles,4-arylamino-2-oxo-1,2-dihydropyridine-3-carbaldehydes,complexes of 4-arylamino-5-formyl-2-oxo-1,2-dihydropyridine-3-carbonitriles with aminoguanidine and guanidine,2-oxo-4-anilino-1,2-dihydropyridine-3-carbonitrile,dimethylformamide dimethylacetal,aminoguanidine,guanidine,X-ray diffraction,antiinflammatory,antidiabetic,antihypertensive activities

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