Increased interleukin-18 expression in nonrheumatic aortic valve stenosis
International Journal of Cardiology(2010)
摘要
Background
It is unknown whether interleukin-18 (IL-18) participates in the pathophysiology of nonrheumatic aortic stenosis (NR-AS).
Methods
We examined IL-18 expression in human NR-AS valves by immunohistochemistry and Western blot analysis.
Results
Immunohistochemistry revealed that NR-AS valves showed increased IL-18 expression compared with controls. IL-18 receptor was also expressed in NR-AS valves. Western blot analysis showed that IL-18 was expressed as an active form in NR-AS valves. Furthermore, increased IL-18 expression was correlated with the advanced clinical severity of NR-AS.
Conclusions
IL-18 was expressed in the aortic valves and up-regulated in NR-AS valves. IL-18 may contribute to the pathophysiology of NR-AS.
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关键词
Aortic stenosis,Cytokine,Inflammation,Interleukin-18
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