Acetylcholine-releasing agents as cognition enhancers. Structure-activity relationships of pyridinyl pendant groups on selected core structures.

Richard A. Earl,Melvyn J. Myers,Alexander L. Johnson,Richard M. Scribner,Mark A. Wuonola,George A. Boswell,Wendell W. Wilkerson,Victor J. Nickolson,S. William Tam,David R. Brittelli,Robert J. Chorvat,Robert Zaczek,Leonard Cook,Chuan Wang,Xusheng Zhang,Rouxi Lan,Baoyu Mi,Hua Wenting

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1992）

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摘要

A number of analogs of the cognition enhancing agent DuP 996 were prepared by varying the core structure and pendant groups in an independent fashion. The SAR of 2-, 3-, and 4-pyridinylmethyl groups as pendant groups on selected cores was examined.

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structure activity relationship

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