Assessment Of Bacille Calmette-Guerin Vaccine Reaction In Hiv-Exposed Thai Infants

Kulkanya Chokephaibulkit,Tawee Chotpitayasunondh,Nirun Vanprapar,Naris Waranawat,Philip A Mock,Michelle S McConnell,Bongkoch Jetswang,Kanchana Neeyapun,Jordan W Tappero,Mary Culnane

CLINICAL INFECTIOUS DISEASES（2007）

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摘要

We evaluated local reactions at 1, 2, and 4 months of age to bacille Calmette-Guerin vaccine given at birth to 1058 infants who were exposed to human immunodeficiency virus (HIV). No scar was discernible in 12 (12.4%) of 97 HIV-infected infants and 20 (2.1%) of 961 uninfected infants (relative risk, 5.9; 95% confidence interval, 3.0-11.8). This difference may reflect poorer immunogenicity in HIV-infected infants.

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clinical research,biology,research methodology,vaccination,primary health care,physiology,developing countries,population,health,immune system

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