8-Methyl-Pyridoxatin:  A NovelN-Hydroxy Pyridone from Fungus OS-F61800 That Induces Erythropoietin in Human Cells

In the course of screening for small-molecule modulators of erythropoietin gene expression, a novel N-hydroxy pyridone was isolated from a culture of OS-F61800. Its structure was elucidated by extensive H-1 and C-13 NMR spectroscopic and chemical studies. This compound induced erythropoietin gene expression fivefold at a concentration of 0.3 mu M, which is about threefold greater potency than our previously identified erythropoietin inducers.