Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality

    American journal of physiology. Endocrinology and metabolism, Volume 295, Issue 3, 2008, Pages E658-64.

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    Keywords:
    recombinant proteinsligationsurvival analysis

    Abstract:

    Sepsis is a multifactorial, and often fatal, disorder typically characterized by widespread inflammation and immune activation with resultant endothelial activation. In the present study, we postulated that the adipokine adiponectin serves as a critical modulator of survival and endothelial activation in sepsis. To this aim, we evaluated ...More

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