Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication
CELL, pp. 673-686, 1990.
genetic engineeringbiotechnologygene transfertransgenicsgeneticsMore(1+)
Transgenic (Tg) mice expressing both Syrian hamster (Ha) and mouse (Mo) prion protein (PrP) genes were used to probe the mechanism of scrapie prion replication. Four Tg lines expressing HaPrP exhibited distinct incubation times ranging from 48 to 277 days, which correlated inversely with HaPrP mRNA and HaPrPC. Bioassays of Tg brain extrac...More
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