2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: Functionally selective GABAA α3-subtype agonists

Robert W. Carling,Michael G.N. Russell,Kevin W. Moore,Andrew Mitchinson,Alexander R Guiblin,Alison J Smith,Keith A. Wafford,George R Marshall,John R. Atack,Leslie J. Street

Bioorganic & Medicinal Chemistry Letters（2006）

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摘要

Novel synthetic routes have been devised for the preparation of previously inaccessible 2,3,7-trisubstituted pyrazolo[1,5-d][1,2,4]triazines 2. These compounds are high affinity, functionally selective ligands for GABAA α3-containing benzodiazepine receptors.

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关键词

GABAA-Benzodiazepine-modulatory-site,Subtype-selective-agonists,Pyrazolo[1,5-d][1,2,4]triazines

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