N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Michael L. Mitchell,Jong Chan Son,Hongyan Guo,Yun-A Im,Eun Jung Cho,Jianhong Wang,Jaclyn Hayes,Michael Wang,Amber Paul,Eric B. Lansdon,James M. Chen,Doris Graupe,Gerry Rhodes,Gong-Xin He,Romas Geleziunas,Lianhong Xu,Choung U. Kim

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

Evaluation of a series of N1-alkyl pyrimidinediones as HIV-1 non-nucleoside reverse transcriptase inhibitors identified compound 10b, which represents the lead compound with pharmacokinetics and antiviral potency that may support once-daily dosing.

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关键词

Human immunodeficiency virus,Reverse transcriptase,Non-nucleoside,Pyrimidinedione

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