Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.

Rena Nishizawa,Toshihiko Nishiyama,Katsuya Hisaichi,Keisuke Hirai,Hiromu Habashita,Yoshikazu Takaoka,Hideaki Tada,Kenji Sagawa,Shiro Shibayama,Kenji Maeda,Hiroaki Mitsuya,Hisao Nakai,Daikichi Fukushima,Masaaki Toda

Bioorganic & Medicinal Chemistry（2010）

引用 21|浏览14

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摘要

Novel spirodiketopiperazine-based CCR5 antagonists, which showed improved pharmacokinetic (PK) profiles without reduction of antagonist activity, were identified.

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关键词

CCR5,Chemokine,Anti HIV

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