BioLabs-On-A-Chip: Monitoring Cells using CMOS Biosensors
Bethesda, MD（2006）
摘要
Cell clinics, CMOS/MEMS hybrid microsystems for capturing and in-situ investigation of living cells, aims at providing high-speed, automated, and economical cell monitoring. Integrated sensors are being developed for extracellular signal amplification, cell-substrate capacitance sensing, contact imaging, and fluorescence detection. We describe the methodology for characterizing the responses of these sensors to biological cells. We also present results obtained from the long-term monitoring of cells cultured on-chip using two of the sensors: (i) a bio-amplifier, used for amplifying weak extracellular potentials from electrically active cells, and (ii) a cell-substrate capacitance sensor, used for tracking cell adhesion and assessing cell viability
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关键词
CMOS image sensors,adhesion,bioMEMS,bioelectric potentials,biosensors,cellular biophysics,fluorescence,lab-on-a-chip,microsensors,optical sensors,CMOS biosensors,CMOS/MEMS hybrid microsystems,bio-amplifier,biolabs-on-a-chip,capacitance sensor,cell adhesion,cell clinics,cell monitoring,cell viability,cell-substrate capacitance sensing,contact imaging,electrically active cells,extracellular potentials,extracellular signal amplification,fluorescence detection,integrated sensors,living cells
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