Complementary addressed modification of double-stranded DNA within a ternary complex

FEBS Letters(1988)

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摘要
Double-stranded DNA containing a d(pG)18·d(pC)18 sequence was shown to be selectively alkylated in the vicinity of this fragment using the 5′-p-(N-2-chloroethyl-N-methylamino)benzylamide of deoxyribooligocytidylate, CIRCH2NH(pdC)n (n = 9, 15), in conditions favouring triple-stranded complex formation.
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关键词
Complementary addressed alkylation,dsDNA
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