Water-soluble PDE4 inhibitors for the treatment of dry eye

Steven P. Govek,Guy Oshiro,John V. Anzola,Clay Beauregard,Jasmine Chen,Avery R. Coyle,Daniel A. Gamache,Mark R. Hellberg,Jennifer N. Hsien,Julia M. Lerch,John C. Liao,James W. Malecha,Lena M. Staszewski,David J. Thomas,John M. Yanni,Stewart A. Noble,Andrew K. Shiau

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

The development of a novel series of water-soluble PDE4 inhibitors led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a tear secretion test in rats.

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关键词

PDE4,PDE4 inhibitor,Dry eye

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