5-Aminopyrimidin-2-ylnitriles as Cathepsin K inhibitors

Andrew D. Morley,Peter W. Kenny,Brenda Burton,Robert A. Heald,Philip A. MacFaul,Julia Mullett,Ken Page,Soraya S. Porres,Lyn Rosenbrier Ribeiro,Phil Smith,Stuart Ward,Tina J. Wilkinson

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

A series of pyrimidine nitrile inhibitors of Cathepsin K with reduced glutathione reactivity has been identified and Molecular Core Matching (MoCoM) has been used to quantify the effect of an amino substituent at C5.

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关键词

Cathepsin K,Cheminformatics,Covalent inhibitor,Covalent adduct,Cysteine protease,Electrophilicity,Glutathione,Leatherface,Matched molecular pair analysis,MMPA,MoCoM,Molecular core matching,Molecule editor,SMARTS

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