Reply to 'Nitrite–methemoglobin inadequate for hypoxic vasodilation'

Bradley I. Goetz, Pamela Wang,Howard W. Shields,Swati Basu,Rozalina Grubina,Jinming Huang,Jeanet Conradie,Zhi Huang,Anne Jeffers,Alice Jiang,Xiaojun He,Ivan Azarov,Ryan Seibert,Atul Mehta,Rakesh Patel,S. Bruce King,Abhik Ghosh,Neil Hogg,Mark T. Gladwin,Daniel B. Kim-Shapiro

NATURE CHEMICAL BIOLOGY（2009）

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摘要

We recently proposed that nitrite-mediated vasodilation involves a reaction between NO and nitrite-bound methemoglobin, Hb(Fe(iii))-NO2−, to form N2O3, thus facilitating export of NO activity from the red blood cell1.

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关键词

Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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