Novel metabolically stable and functionally active mimetic of spermidine
Russian Journal of Bioorganic Chemistry(2011)
摘要
Earlier unknown 1,8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1 -acetyltransferase nor spermine synthase, but was capable to support the growth of DU145 cells having depleted polyamine pools. Such a combination of γ-MeSpd properties discloses novel opportunities to study cellular functions of catabolically unstable and easily interconvertible spermine and spermidine.
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关键词
spermine/spermidine N 1 -acetyltransferase
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