Fluorescent and photodynamic properties of near-infrared photosensitizer bacteriochlorophyllide-serine

I G Meerovich,Irina Yu Kubasova,N A Oborotova,Gennadii A Meerovich,Shinichi Demura,A Brandis,Varda Rosenbachbelkin,Anatoly Yu Baryshnikov,Avigdor Scherz

PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE)（2005）

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摘要

Study is devoted to investigation of fluorescent and photodynamic properties of near-infrared photosensitizer bacteriochloriphyllide-serine. The peculiarities of its fluorescence excited by different lasers, dynamics and selectivity of accumulation were investigated. Photodynamic therapy of mice and investigation of tissue de-oxygenation during tumor irradiation were performed. It was shown that bacteriochloriphyllide-serine is an effective photosensitizer for PDT and fluorescent diagnostics of tumors.

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关键词

vessel alterations.,fluorescence,pdt,tumor,laser,bchl-ser,bacteriochloriphyllide-serine,photosensitizer,near infrared,lasers,luminescence

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