Pharmacokinetics Of Cefoxitin In Premature And Newborn-Infants Studied By Continuous Serum Level Monitoring During Combination Therapy With Penicillin And Amikacin

A microbiological method was developed for measuring cefoxitin serum levels in newborns with septicemia who were being treated with a combination of cefoxitin, amikacin and penicillin G. Serum specimens were taken at random intervals during treatment and basic pharmacokinetic data such as volume of distribution, clearance and rate constant of elimination were calculated using a computer based programme. A dosage of 100 mg/kg cefoxitin three times daily yielded effective blood levels without accumulation of the drug in the serum during a ten day treatment period. The volume of distribution by far exceeded the intravascular volume so it can be assumed that effective tissue concentrations were achieved.