CCR5 receptor antagonists: Discovery and SAR study of guanylhydrazone derivatives

Robert G. Wei,Damian O. Arnaiz,Yuo-Ling Chou,Dave Davey,Laura Dunning,Wheeseong Lee,Shou-Fu Lu,James Onuffer,Bin Ye,Gary Phillips

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

High throughput screening (HTS) led to the identification of the guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde as a CCR5 receptor antagonist. Modifications of the guanylhydrazone resulted in the discovery of novel CCR5 antagonists.

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关键词

CCR5,Chemokine receptor antagonists

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