Considering the role of pyruvate in tumor cells during hypoxia.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer（2009）
摘要
Impairment of oxygen supply occurs in many pathological situations. In the case of cancer, both chronic and acute hypoxic areas are found in the tumor. Tumor hypoxia is associated with poor clinical prognoses and is correlated with tumor growth and metastasis development.
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关键词
ATP,acetyl-CoA,CAM,NAD,NADH,FGFR-2,GSH,HIF,HK-2,HSP,MCT1,PARP,PDK1,ROS,VEGF
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