Neurocytoprotective effects of the bioactive constituents of Pueraria thomsonii in 6-hydroxydopamine (6-OHDA)-treated nerve growth factor (NGF)-differentiated PC12 cells

Chien-Min Lin,Rong-Dih Lin,Shui-Tein Chen,Yi-Pei Lin,Wen-Ta Chiu,Jia-Wei Lin,Feng-Lin Hsu,Mei-Hsien Lee

Phytochemistry（2010）

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摘要

Daidzein (1) and genistein (4), isolated from Pueraria thomsonii (Fabaceae) have neurocytoprotective effects against 6-hydroxydopamine (6-OHDA)-induced cytotoxicity in nerve growth factor (NGF)-differentiated PC12 cells. They were effective in blocking the early and late apoptotic protective mechanisms against 6-OHDA-induced neurocytotoxicity.

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关键词

Pueraria thomsonii Benth.,Fabaceae,PC12 cells,6-Hydroxydopamine,Daidzein,Genistein,Neurocytoprotection

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