Synthesis of potent pyrrolidine influenza neuraminidase inhibitors

A. Chris Krueger,Yibo Xu,Warren M. Kati,Dale J. Kempf,Clarence J. Maring,Keith F. McDaniel,Akhteruzzaman Molla,Debra Montgomery,William E. Kohlbrenner

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

The synthesis of several pyrrolidine inhibitor analogs is described that possess nanomolar in vitro potencies against the neuraminidase enzymes expressed by the B/Memphis/3/89 and A/N1/PR/8/34 influenza strains.

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关键词

Influenza,Neuraminidase,Pyrrolidine

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