Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology

Brain : a journal of neurology, Volume 130, Issue Pt 4, 2007, Pages 1089-1104.

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Keywords:
multiple sclerosisdemyelinationb cellsneurodegenerationectopic follicles

Abstract:

Intrathecal antibody production is a hallmark of multiple sclerosis and humoral immunity is thought to play an important role in the inflammatory response and development of demyelinated lesions. The presence of lymphoid follicle-like structures in the cerebral meninges of some multiple sclerosis patients indicates that B-cell maturation ...More

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