Design driven HtL: The discovery and synthesis of new high efficacy β2-agonists
Bioorganic & Medicinal Chemistry Letters(2011)
摘要
The design and synthesis of a new series of high efficacy β2-agonists devoid of the key benzylic alcohol present in previously described highly efficacious β2-agonists is reported. A hypothesis for the unprecedented level of efficacy is proposed based on considerations of β2AR crystal structure, other biophysical data and modeling studies.
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关键词
LABA,β2-Agonists,Adrenoreceptor agonist,Asthma,COPD,Inhaled
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