Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors.
Bioorganic & Medicinal Chemistry Letters（2005）
摘要
The synthesis and SAR studies on triazole-containing tubulin inhibitor class are reported.
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关键词
Tubulin inhibitor,Tubulin polymerization,1,2,4-Triazole,Vascular disrupting agent,Tumor vasculature,Antimitotic
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