Pharmacokinetic Properties of Phosphorothioate Oligonucleotides

Janet Leeds,Richard Geary,Scott Henry,Jo Glover,William Shanahan,Jon Fitchett,Todd Burckin, LoAnne Tmong,Arthur Levin

NUCLEOSIDES & NUCLEOTIDES（1997）

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摘要

The pharmacokinetic parameters determined for different phosphorothioate oligonucleotides were compared. The data suggest that phosphorothioate pharmacokinetics are primarily determined by chemical class. The pharmacokinetics are consistent across species, show dose-dependency, and are independent of sequence.

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