Synthesis and intestinal transport of the iron chelator maltosine in free and dipeptide form.

Stefanie Geissler,Michael Hellwig,Fritz Markwardt,Thomas Henle,Matthias Brandsch

European Journal of Pharmaceutics and Biopharmaceutics（2011）

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摘要

The oral bioavailability of the iron chelator maltosine might be increased by applying this drug candidate in peptide-bound form. Alanylmaltosine and maltosinylalanine are transported by the intestinal proton-coupled peptide transporter 1 (PEPT1) into intestinal cells.

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关键词

Maillard reaction,Intestine,PEPT1,Iron chelator,3-Hydroxy-4-pyridinone,Prodrug

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